Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Wisconsin, Madison
With
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Age
18–50
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18-50 years
Diagnosis of allergic rhinitis and/or mild asthma
Pre-albuterol forced expiratory volume in the first second (FEV1) of \>70% predicted.
Skin test positive to house dust mite (D. farinae), short ragweed or cat hair
Documented negative Tuberculin skin test (PPD) within the last 12 months or a medical history that is consistent with a low probability of exposure to tuberculosis (i.e. the subject is not a health worker, has not traveled to endemic areas, and has no pre-existing medical or social risk factors for tuberculosis).
At least a 20% decrease in FEV1 during the immediate response following inhaled antigen challenge
Safety laboratory assessments within normal ranges (labs to include complete blood count with differential, blood urea nitrogen, creatinine, Prothrombin time, Partial Thromboplastin Time and platelet count)
Women of child-bearing potential (WCBP) must have a negative urine pregnancy test (urine HCG) within 48 hours of the methacholine challenge at Visit 2, within 48 hours of the inhaled allergen challenge at V3 and on the day of the segmental allergen challenge on Visit 5. WCBP must agree to use a reliable method of birth control for the duration of the study (reliable methods of birth control can include abstinence, barrier methods, oral contraceptives, injection contraceptives or skin absorption contraceptives).
In the opinion of the investigator, capable and willing to grant written informed consent and cooperate with study procedures and requirements
You may not be if
Major health problems such as autoimmune disease, heart disease, type I and II diabetes, uncontrolled hypertension or lung diseases other than asthma. The listed health problems are definitive exclusion but decisions regarding major health problems not listed will be based upon the judgment of the investigator.
No pre-existing chronic infectious disease.
Any condition for which, in the opinion of the investigator, transient oxyhemoglobin desaturation is inadvisable.
Pregnant or lactating females or has a planned pregnancy during the course of the study.
Medication other than for asthma, allergies or contraception (e.g. monoamine oxidase inhibitors and beta-adrenergic antagonists in any form).
Inhaled corticosteroids or oral corticosteroids within 1 month of screening.
Upper or lower respiratory infection within 1 month of screening.
Unstable asthma as indicated by self report of increased symptoms or increased beta-agonist use over the 2 weeks preceding the screening visit.
Current smokers (defined as smoked within the last year) or a former smoker with a history of \>5 pack years.
Obesity as defined by a Body Mass Index (BMI) \>30.
Use of an investigational drug within 30 days of entering the study
History of noncompliance with medical regiments or subjects who are considered unreliable including those with a psychiatric history that, in the opinion of the investigator, may interfere with the conduct of study procedures.
Clareo Health | Functional Activity of Airway Eosinophils in Allergic Disease
