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COMPLETEDNCT01023451

Serum Brain Natriuretic Peptide Levels and Pulmonary Hypertension in Pediatric Sickle Cell Patients

The purpose of this study is 1. To determine if Brain natriuretic peptide levels correlates with elevated tricuspid regurgitation flow velocity levels in pediatric patients with sickle cell disease 2...

Lead sponsor: Akron Children's Hospital•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Akron Children's Hospital

Pulmonary hypertension is recognized as a significant cause of morbidity and mortality in patients with sickle cell disease. Doppler echocardiography is a recommended noninvasive screening tool for sickle cell disease patients with pulmonary hypertension. Brain natriuretic peptide levels have been found to be a possible serum screening marker. This research will offer the opportunity to determine if there is any possible relationship between magnitude of BNP concentration and degree of TRV, if it can be used as a screening test in SCD pediatric patients with PHT and form the basis for a future multicenter study

Age

7 - 21 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Male and Female any age
•Diagnosis of SCD with PHT on echocardiogram
•Controls must have a diagnosis of sickle cell disease without Pulmonary hypertension, age, gender and disease type match to subjects with pulmonary hypertension
•Parent or Legal guardian willing to sign informed consent form

Exclusion Criteria

•Abnormal echocardiograms not related to PHT
•Parent or Legal guardian unwilling or unable to give written informed consent

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: June 26, 2014Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment21

Start dateDec 2009

Last updatedJun 26, 2014

Condition

Pulmonary Hypertension

Locations shown

Akron Children's Hospital Sickle Cell Clinic

Akron, Ohio

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 26, 2014Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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