Lead Sponsor

Belfast Health and Social Care Trust

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

No

•New York Heart Association Class II and III
•Already on or tried on best known medical treatment (ACE inhibitor and beta-blocker)
•Stable for a period of at least 6 weeks
•Left ventricular ejection fraction less than or equal to 45%

•History of significant alcohol ingestion (more than 40 units per week)
•Severe renal dysfunction (GFR less than 30ml/min)
•Severe hepatic dysfunction (known liver disease or transaminases greater than 3 times the upper limit of normal)
•Atrial fibrillation (in the absence of a pacemaker)
•Frequent ventricular ectopics
•On waiting list for cardiac transplantation
•Uncontrolled diabetes mellitus
•Inability to give informed consent
•Estimated life span less than 12 months
•Already taking a multivitamin/mineral supplement
•Already taking a vitamin-D containing fish oil
•Woman of child-bearing potential
•History of renal stones, hypercalcaemia, sarcoidosis, haemochromatosis or lactose intolerance