Antibody Persistence & Immune Memory in Healthy Adults Previously Vaccinated With Twinrix Adult

Exclusion Criteria

• •The following criteria should be checked before entry into each of the long-term follow-up visits. If any exclusion criterion applies, the subject must not be included in the study:
• •Use of any investigational or non-registered product within 30 days prior to blood sampling.
• •Administration of a hepatitis A, hepatitis B or combined hepatitis A and B vaccine outside the study procedures, since the primary study HAB-028 (208127/021).
• •History of hepatitis A or hepatitis B infection since the primary study HAB-028 (208127/021).
• •Administration of hepatitis A or hepatitis B immunoglobulins and/or any blood products within three months prior to blood sampling.
• •The following criteria should be checked before the challenge dose is administered. If any apply, the subject must not be included in the challenge dose phase:
• •Use of any investigational or non-registered product within 30 days prior to study start or planned use during the study.
• •Administration of a hepatitis A, hepatitis B or combined hepatitis A and B vaccine between the last LTFU visit and the challenge dose visit.
• •History of hepatitis A or hepatitis B infection between the last LTFU visit and the challenge dose visit.
• •History of anaphylactic reactions following the administration of vaccines.
• •History of any reaction or hypersensitivity likely to be exacerbated by any component of the vaccines.
• •Acute disease and/or fever at the time of enrolment.
• •Pregnant or lactating female.
• •Female planning to become pregnant or planning to discontinue contraceptive precautions.