Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
With
National Cancer Institute (NCI)
North American Brain Tumor Consortium
OBJECTIVES:
* Determine the frequency and severity of decreases in CD4 counts as a function of therapy in patients with newly diagnosed malignant astrocytoma.
* Determine whether the decrease in CD4 counts is a significant predictor of infections or adverse outcomes in these patients.
OUTLINE: This is a multicenter study.
Patients undergo monthly collection of blood for serial CD4 counts and heme-8 with differential for 1 year for quantitative analysis. Patients also complete a monthly questionnaire about infections and antibiotic use.
Patients are followed every 2 months.
PROJECTED ACCRUAL: A total of 125 patients (100 with high-grade disease and 25 with low-grade disease) will be accrued for this study.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
DISEASE CHARACTERISTICS:
Histologically confirmed primary malignant brain tumor in 1 of the following groups:
* High grade (grade III or IV) supratentorial glioma receiving antineoplastic treatment and with 1 of the following histologies:
* Anaplastic astrocytoma
* Glioblastoma multiforme (giant cell glioblastoma or gliosarcoma)
* Anaplastic oligodendroma
* Low grade (grade I or II) supratentorial glioma not planning to receive treatment of any kind (including steroids) and with 1 of the following histologies:
* Astrocytoma
* Oligodendroglioma
PATIENT CHARACTERISTICS:
Karnofsky performance status 60-100%
No HIV positivity
PRIOR CONCURRENT THERAPY:
No prior chemotherapy for brain tumor except polifeprosan 20 with carmustine implant (Gliadel® wafer)
No prior cranial radiotherapy or radiotherapy for brain tumor
No prior immunotherapy or biologic agents for brain tumor, including any of the following:
* Immunotoxins
* Immunoconjugates
* Peptide receptor antagonists
* Interleukins
* Interferons
* Tumor-infiltrating lymphocytes
* Lymphokine-activated killer cell therapy
* Gene therapy
* Antisense therapy
No prior hormonal therapy for brain tumor
* More than 14 days since prior and no concurrent steroid therapy for patients with low-grade (grade I or II) astrocytoma
* Prior glucocorticoid therapy allowed
Clareo Health | Study of Blood Samples and Risk of Infection in Patients With Newly Diagnosed Malignant Supratentorial Astrocytoma
