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COMPLETEDPhase 1NCT00990223

Effects Of Eplerenone On Serum Aldesterone And Plasma Renin Activity

To evaluate the changes in serum aldosterone and plasma renin activity on Day 0 and on Days 1 and 10 after administration of 100 mg of eplerenone daily for 10 days.

Lead sponsor: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.•2 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Age

18 - 55 years

Sex

MALE

Healthy Volunteers

Yes

Inclusion Criteria

•Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lbs)
•Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.

Exclusion Criteria

•Evidence or history of clinically significant disease
•Subjects with a supine BP greater than or equal to 140 mm Hg systolic or greater than or equal to 90 mm Hg diastolic or \<100 mm Hg systolic and \<60 mm Hg diastolic on a single measurement, as described in the protocol
•Blood donation of approximately 1 pint (500 mL) within 56 days prior to dosing
•History of sensitivity to eplerenone, spironolactone or related compounds.
•Serum potassium \>5.0 mEq/L at screening or Day 0

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: December 22, 2020Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE1

Enrollment20

Start dateOct 2009

Last updatedDec 22, 2020

Condition

Healthy Volunteers

Locations shown

Pfizer Investigational Site

Miami, Florida

Pfizer Investigational Site

South Miami, Florida

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 22, 2020Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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