Pioglitazone in Alzheimer Disease

Exclusion Criteria

• •Absence of a reliable caregiver who is willing to participate and comply with protocol responsibilities
• •Diabetes mellitus requiring medical therapy (diet-controlled diabetes is acceptable)
• •Acute or chronic liver failure, hepatitis within the last two years, or history of drug-induced liver transaminase elevations
• •Heart failure meeting New York Heart Association Grade III or IV criteria (i.e., functionally disabling)
• •Evidence of active gastrointestinal, renal, pulmonary, endocrine or cardiovascular system disease sufficient to cause cognitive impairment or interfere with past levels of daily function; participants with controlled hypertension (supine diastolic BP \< 95mmHg), right bundle branch block (complete or partial) and pacemakers may be included in the study; participants with thyroid disease also may be included in the study, provided they are euthyroid on treatment
• •Active treatment for cancer or history of cancer within 3 years of screening (basal cell and squamous cells skin cancers are acceptable; incidental finding of carcinoma cells at transurethral prostate resection without subsequent medical or surgical therapy is acceptable)
• •Evidence of other psychiatric/neurologic disorders sufficient to be the primary source of cognitive impairment (i.e., stroke, idiopathic Parkinson's disease, schizophrenia, bipolar or unipolar depression, seizure disorder, head injury with loss of consciousness within the past year) or a modified Hachinski's ischemia score of 5 or greater; delusions, hallucinations or depression not successfully treated or not on stable medical therapy for these conditions 30 days prior to enrollment; known or suspected history (within the past 10 years) of alcoholism or drug misuse
• •Participants and/or caregivers who are unwilling or unable to fulfill the requirements of the study
• •Any condition which would make the participant or the caregiver, in the opinion of the investigator, unsuitable for the study