Medication Adherence in Schizophrenia: Development of a CBT-Based Intervention

Exclusion Criteria

• •1. Unable to understand informed consent process
• •2. A history of nonresponse to prior antipsychotic trials such that long-term inpatient treatment or clozapine will be recommended
• •3. Prior treatment with clozapine
• •4. Discharge from inpatient treatment for psychotic symptoms, initial treatment, or provisional diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform occurred more than 6 months from enrollment into the evaluation phase
• •5. Pregnancy or stated goal to become pregnant
• •6. Will not be living close enough to the medical center to return for follow-up visits or assessments
• •7. History of geographic instability such that it is judged unlikely that patient will reside in the area
• •8. Currently under arrest for a felony, or an arrest is deemed likely in the near future
• •9. Currently receiving medication over objection by court order
• •10. Currently receiving treatment in another research protocol
• •1. Diagnosis or inpatient treatment for psychotic symptoms occurred more than 6 months from date of enrollment into evaluation phase
• •2. Acutely psychotic individuals may not participate because therapy will not benefit if symptoms are too severe
• •3. Has dropped out of the treatment program and cannot be located for follow-up appointments
• •4. Stated refusal to come for to at least one clinical evaluation appointment at the PDP, or has been a "no show" for at least three consecutive appointments
• •5. Judged to be at significant and imminent risk of harm to self or others\*
• •6. Ongoing active substance or alcohol use that is not controlled during the Evaluation Phase, along with refusal of referral to a "dual diagnosis" treatment program for substance abuse problems
• •7. Remains enrolled in another research protocol at UIC\*
• •8. Unwilling to consider any additional psychotherapeutic intervention above and beyond coming in to the service for medication management appointment
• •9. Baseline PANSS total score ≥ 90, or has a individual PANSS item of conceptual disorganization (item P2), excitement (P4), or hostility (P7) that is ≥ 5 (moderately severe)\*
• •10. Judged to require additional concrete case management services to support medication adherence\*
• •11. Receives antipsychotics under coercive conditions (e.g. inpatient or outpatient commitment)\*