Trial of Vitamin D Supplementation in Chronic Obstructive Pulmonary Disease

Exclusion Criteria

• •Current diagnosis of asthma
• •Known clinically significant bronchiectasis
• •Known sarcoidosis, hyperparathyroidism, nephrolithiasis, active tuberculosis, vitamin D intolerance, liver failure, renal failure, terminal illness, lymphoma or other malignancy not in remission for ≥ 3 years
• •Taking benzothiadiazine derivative, cardiac glycoside, carbamazepine, phenobarbital, phenytoin or primidone
• •Taking dietary supplement or topical preparation containing vitamin D up to 2 months before first dose of IMP
• •Treatment with any investigational medical product or device up to 4 months before first dose of IMP
• •Breastfeeding, pregnant or planning a pregnancy
• •Baseline corrected serum calcium \> 2.65 mmol/L
• •Baseline serum creatinine \> 125 micromol/L