Selective Internal Radiation Therapy (SIRT) in Patients With Unresectable Colorectal Cancer Liver Metastases Who Failed Prior Intraarterial Pump Chemotherapy

Inclusion Criteria

• •Histologic confirmation of colorectal cancer.
• •Unequivocal imaging of hepatic metastases.
• •Dominant Liver metastases. (Small amount extrahepatic disease allowed.)
• •Unresectable liver metastases.
• •Liver Metastases non-eligible for, or progressed after ablation
• •Failed prior HAC.
• •ECOG performance status 0 - 1
• •WBC \> or = to 1.5 x 109/L
• •Platelets \> or = to 50 x 109/L
• •Creatinine ≤ 1.5 mg/dl
• •Bilirubin ≤ 1.5 mg/dl
• •Age \> or = to 18 years
• •Female patients must either be postmenopausal, sterile (surgically or radiation- or chemically-induced), or if sexually active, must agree to use an acceptable method of contraception.
• •Male patients must be surgically sterile, or if sexually active, must agree to use an acceptable method of contraception.
• •Life expectancy of at least 3 months without any active treatment.
• •No chemotherapy regimen administration for at least 4 weeks prior to SIRT administration