Safety and Efficacy of Brinzolamide/Brimonidine Fixed Combination

Exclusion Criteria

• •Females of childbearing potential if pregnant, lactating, or not using highly effective birth control measures.
• •Any form of glaucoma other than open-angle glaucoma.
• •Severe central vision loss in either eye.
• •Chronic, recurrent, or severe inflammatory eye disease.
• •Ocular trauma within the preceding 6 months.
• •Ocular infection or ocular inflammation within the preceding 3 months.
• •Clinically significant or progressive retinal disease such as retinal degeneration, diabetic retinopathy, or retinal detachment.
• •Best-corrected visual acuity score worse than 55 letters using the Early Treatment Diabetic Retinopathy Study chart.
• •Other ocular pathology (including severe dry eye) that may, in the opinion of the Investigator, preclude the administration of study product.
• •Ocular surgery within the preceding 6 months.
• •Ocular laser surgery within the preceding 3 months.
• •Any abnormality preventing reliable applanation tonometry.
• •Any other conditions, including severe illness, which could make the patient, in the opinion of the Investigator, unsuitable for the study.