Lead Sponsor

Christiana Care Health Services

Collaborators

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

No

•1. Individuals aged 18 - 60 years old.
•2. Individuals with a BMI \> 35 kg/m2.
•3. Patients that have enrolled in a program to undergo weight loss by Roux-en-Y gastric bypass and having passed the pre-operative clearance program.
•4. Individuals with diabetes who are currently being treated with diet, exercise, and/or oral medications will be included.

•1. Patients that have had previous gastric surgery, including but not limited to pancreobiliary diversion, vertical banded gastroplasty, and jejunoileostomy.
•2. Individuals with known coronary artery disease (e.g., post-MI), atrial fibrillation,frequent atrial arrhythmias, frequent ventricular arrhythmias, a pacemaker, or myocardial ischemia.
•3. Individuals taking the following medications that may affect the autonomic nervous system: anti- tuberculosis drugs, nitrofurantoin, metronidazole, chloramphenicol,perhexiline maleate, amiodarone, clofibrate, tricyclic antidepressants, phenytoin,methotrexate, barbiturates, neuroleptic drugs, antiparkinsonism drugs, fluoxetine, and nitrated drugs.

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