Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Asahi Kasei Medical Co., Ltd.
With
Asahi Kasei Medical Europe GmbH
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients diagnosed to have UC in the active stage based on clinical symptoms and findings from endoscopy
Patients with pancolitis type or left-sided colitis type lesion of 15 cm or longer observed endoscopically
Patients with Mayo score between 5 and 10
Patients with Mayo sub-score (findings from flexible sigmoidoscopy) of 2 or 3
Patients not having received any corticosteroids (referred to as steroids) (p.o., i.v., enema, suppository) within the past 6 weeks
You may not be if
Patients with a difficulty in peripheral vascular access
Patients having received ACE inhibitor (at least 10 times of its half-life time for interval needed before initiating the treatment)
Patients with toxic megacolon
Patients with a malignant disease or its experience
Patients with a severe cardiovascular disease (grade III or IV by the Classification of heart functions of the New York Heart Association (NYHA))
Patients with a liver or kidney disease (AST(GOT) or ALT(GPT) or total bilirubin or creatinine level which is 2 or more times higher than the upper limit of normal (abbreviated as ULN, hereinafter)
Patients suspected to have or having HBV or HCV or HIV or pathogenic bacteria
Patients on anticoagulant therapy or with abnormality in the blood coagulation system (PT or PTT levels which are 1.5 or more times higher than ULN
Pregnant women or patients with possible pregnancy
Breast feeding women
Patients weighing 40 kg or less
Patients with hemoglobin level of less than 6.5 mmol/L (10.5 g/dL)
Patients with platelet count of less than 150 x 103/mm3, 150 x 109/L (15 x 104/mm3)
Patients with white blood cell count of less than 3.5 x 109/L (3,500/mm3)
Patients with hypotension (with systolic blood pressure of 80 mmHg or less)
