Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
PharmaEngine
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Histopathologically confirmed metastatic colorectal cancer
Documented disease progression after first-line chemotherapy containing oxaliplatin
Both genders, age 18 years
ECOG performance status 0 or 1
Adequate organ and marrow function
Written informed consent to participate in the study
You may not be if
Have received irinotecan treatment
With active CNS metastases (indicated by clinical symptoms, cerebral edema, steroid requirement, or progressive growth)
With clinically significant gastrointestinal disorder (e.g. bleeding, inflammation, obstruction, including partial or complete obstruction secondary to peritoneal carcinomatosis, or diarrhea \> grade 1)
With uncontrolled intercurrent illness that could limit study compliance considered to be ineligible for the study by the investigators including, but NOT limited to, any of the following:ongoing or active infection requiring antibiotic treatment, symptomatic congestive heart failure, unstable angina pectoris, or cardiac arrhythmia psychiatric illness or social situation that would preclude study compliance
With other primary malignancies, except those remain disease-free for 3 or more years after curative treatment.
Prior chemotherapy within 3 weeks
Major surgery or radiotherapy within 4 weeks
Prior participation in any investigational drug study within 3 weeks
History of allergic reaction to liposome product
Pregnant or breastfeeding (a urine pregnancy test must be performed on all patients who are of childbearing potential before entering the study, and the result must be negative)
