Pre-eclampsia and Metabolomics

Metabolomics involves a new technology using the methods of separation and detection complex to investigate a set of small molecules that characterize biochemical pathways of interest. The change in concentration levels of these molecules in various biological samples such as urine and blood in the presence of a disease or a patient can detect metabolic fingerprints that can be particularly useful for identifying new biomarkers. These will thereafter be quantified and validated by metabolic profiling. To our knowledge, there are few studies on metabolomics and pregnancy. Methods: The studied population will be women hospitalized for preeclampsia (after 20 SA). Women in the control group will be matched to women hospitalized for pre-eclampsia according to gestational age at diagnosis of pre-eclampsia, maternal age, parity, ethnicity and body mass index. Blood and urine samples will be taken: Case control: * Following the diagnosis of preeclampsia * At each blood test requested by the physician during the follow-up * When the patient will be in labor (cervix ripening \> 5 cm) or before the caesarean section * 48 hours after delivery * 6-8 weeks after delivery Control group: * Following the inclusion as a control in the study * At admission for delivery * When the patient will be in labor (dilation \> 5 cm) or before the caesarean section * 48 hours after delivery * 6-8 weeks after delivery