Effect of Rosuvastatin Therapy in Patients With Stable Chronic Obstructive Pulmonary Disease

Exclusion Criteria

• •Diagnosed lung disease other than COPD, except chronic asthmatic bronchitis and mild bronchiectasis without or few physical signs (diagnosed by high resolution CT)
• •History of or active coronary artery disease (CAD), cerebrovascular or peripheral vascular disease
• •History of or clinically significant congestive heart failure, valvular heart disease, clinically significant arrhythmias or conduction delays
• •History of uncontrolled arterial hypertension (defined as blood pressure above180/110 mmHg with or without the use of antihypertensive medication)
• •Body mass index \>40kg/m2
• •History of diabetes mellitus, measured fasting glucose \> 11 mmol/L
• •History of Hypercholesterolemia, measured total cholesterol \> 8 mmol/L
• •Known poliomyelitis, motor neurone disease, cranial or temporal arteritis, stroke or myopathy
• •Neutropenia, anemia (Hb \< 8 g/100mL)
• •History of chronic renal failure, serum creatinine \> 176 micromol/L (2.0mg/dL)
• •Creatine kinase \> 3 times the upper limit of normal (ULN)
• •Acute or chronic liver disease (serum transaminases \> 3 times the ULN)
• •Pregnancy (oral examination and blood test prior to inclusion)
• •Active abuse of drugs or alcohol, poor compliance anticipated
• •Statin use within the last 4 weeks prior to study start or previously clear indication for statin use
• •Prior diagnosis of statin induced myopathy or hypersensitivity reaction to another hydroxymethylglutaryl-Coenzyme A-reductase inhibitor incl. Rosuvastatin
• •History of malignant disease of any kind within 5 years prior to inclusion.
• •History of uncontrolled hypothyroidism
• •Participation in another pharmaceutical or medical device clinical trial study less than 4 weeks prior inclusion.
• •Use concomitant of medications that are known to interact with Crestor. This includes the following medications: Warfarin and other coumarin (vitamin K antagonist) anticoagulants, Cyclosporin, Gemfibrozil and Antacid