Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Institut Claudius Regaud
With
PHARMACIA SAS
Age
60–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Breast cancer histologically proven by a 14 G or 16 G micro-biopsy to have confirmation of the diagnosis, evaluation histology prognosis grade, hormone receptors and to obtain a sample for the study of biological factors.
Menopausal patients as defined as follows:
* Natural menopause \>= 1 year, or
* Surgical ovariectomy.
T unilateral tumor\> 3 cm, N 1-2, M0 or M +, non-inflammatory.
Hormone receptor positive. RE positive or PR positive with histochemical technique (+ 10% of cells express the receptor)
No previous treatment of the disease by chemotherapy, hormone therapy, surgery or radiotherapy. Discontinuation of replacement therapy of menopause for at least 1 month
Age\>= 60 years
Evaluable disease
Performance Status \<= 2
Biological function using the following criteria:
* neutrophils \>= 2.10E9 / l,
* Platelets\> = 100.10E9 / l,
* Hemoglobin\> = 10 g / dl,
* Creatinine \<= 1.5 x upper normal,
* Total bilirubin \<= 1.25 x the upper normal
* Transaminases (AST and ALT) \<= 1.5 x upper normal,
* Alkaline phosphatase \<= 2.5 x upper normal.
Cardiac Function: electrocardiogram (ECG) normal.
Signed written consent before any procedure related to the study.
You may not be if
Men
Non Menopausal Patients
Patients with hormone receptor negative: PR- and RE -
Contra-indication to anti-estrogens (risk thrombi arteria)
Tumor \<3 cm operable
Tumor inflammatory T4d (PEV 2 or 3).
Extensive hepatic lesions (\> 1 / 3 of liver volume)
Uncontrolled cardiac disease such as angina, congestive heart failure, or arrhythmia requiring medical treatment or history of myocardial infarction within 3 months before.
History of cancer except skin cancer and basal cell cancer in situ of the cervix (a contralateral breast cancer had been no systemic treatment will be admitted).
Chronic diseases (somatic or psychiatric) in poor prognosis.
Patients who for reasons of family, social, geographical or psychological can not be followed properly.
