Age

18–50

Sex

ALL

Healthy volunteers

Not accepted

definitive multiple sclerosis according to Mc Donald criteria
clinical isolated syndrome according to Mc Donald criteria
Expanded Disability Status Scale Score 0-5
Pre-treatment with interferon beta 1a (Avonex) since at least 2 months before inclusion

relapse within 30 days prior to randomisation
steroid pulse therapy within 30 days prior to randomisation
pregnancy or poor contraception
contraindication for lamotrigine
depressive symptoms
drugs with possible interaction with lamotrigine according to instruction leaflet
other medical relevant conditions but multiple sclerosis
clinically relevant laboratory results
contraindication for MRI
missing informed consent

The Neuroprotective Effect of Lamotrigine and Interferon Beta 1a in Patients With Relapsing-Remitting Multiple Sclerosis