Lead Sponsor

National Institute of Mental Health and Neuro Sciences, India

Age

17 - 50 years

Sex

ALL

Healthy Volunteers

No

•Patients fulfilling DSMIV Criteria for Schizophrenia
•The patient should be drug naïve or drug free for one month (oral antipsychotic) or three months of parental antipsychotic
•Duration from onset \< 5 years
•Informed consent

•Patient with any other current Axis I or Axis II comorbid disorders
•Comorbid substance abuse or dependence except nicotine or caffeine
•Presence of significant medical disorder such as epilepsy, uncontrolled hypertension and diabetes mellitus, thyroid disorder
•Patient who has not responded to adequate course of risperidone (with reference to dose and duration)
•Treatment-resistant schizophrenia defined as non-response to three different antipsychotics belonging to at least two different classes, one of which is an atypical agent and one of which is a depot neuroleptic
•Patient who has received ECT in past 3 months