Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Merck Sharp & Dohme LLC
Age
35–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Female participants must be post-menopausal
Body Mass Index (BMI) of at least 29 kg/m\^2
Weight has been stable over the past 3 months
Has never been treated for hypertension or is diagnosed with hypertension taking up to 2 anti-hypertensive medications
Willing to stop hypertension treatment for 14 days prior to randomization and throughout the study
Does not have a history of diabetes
In good health with the exception of hypertension
No history of abnormal heart rhythms
Part I only: willing to comply with high potassium/low sodium diet for the duration of the study
Willing to avoid strenuous physical activity during the study
Nonsmoker and/or has not used nicotine for at least 3 months and agrees to refrain from use of tobacco-containing products throughout the study
Agrees to refrain from consuming alcohol and caffeine during in-patient periods and to limit consumption at all other times during the study
Agrees not to consume grapefruit, grapefruit products, and citrus, apple, and pineapple juices 2 weeks prior to administration of the first dose of study drug
You may not be if
History of any illness that may make their participation in the study unsafe or confuse the study results
Taking spironolactone or eplerenone
Cannot refrain from using any prescription or non-prescription drugs during the study
On a weight loss program and is not in the maintenance phase
Started a weight loss drug within 8 weeks of the first study visit
Consumes excessive amounts of alcohol or caffeine
Has had major surgery, donated or lost 1 unit of blood within 4 weeks of the first study visit
History of multiple and/or severe allergies to drugs or food
Is dehydrated
Clareo Health | Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed)
