Histologically confirmed WHO grades 3 to 4 malignant glioma

Diagnosed recurrence or progression by clinical or radiological evidence

Fit for intraarterial infusion and intravenous chemotherapy

Adequate hepatic, renal, and hematologic function.

Legal age ≥18 years

Life expectancy ≥12 weeks

Eastern Cooperative Oncology Group performance (ECOG) ≥2

Chemotherapy completion ≥4 weeks prior and recovery from drug induced toxicities.

ADV-TK Improves Outcome of Recurrent High-Grade Glioma