Next DPI LABA, Multicentre, 5-way Cross-over, Adult Asthmatic Patients

Exclusion Criteria

• •Pregnant or lactating women or all women physiologically capable of becoming pregnant UNLESS they are menopausal or are using effective and acceptable methods of contraception.
• •Significant seasonal variation in asthma or asthma occurring only during episodic exposure to an allergen or a chemical sensitizer.
• •History of near fatal asthma (e.g. brittle asthma, hospitalisation for asthma exacerbation in Intensive Care Unit) within 1 year before screening.
• •Occurrence of asthma exacerbations or respiratory tract infections in the 4 weeks preceding the screening visit.
• •Diagnosis of Chronic Obstructive Pulmonary Disease (COPD)
• •History of cystic fibrosis, bronchiectasis or alpha-1 antitrypsin deficiency.
• •Diagnosis of restrictive lung disease.
• •Patients treated with oral or parenteral corticosteroids in the previous 8 weeks (12 weeks for parenteral depot corticosteroids) before screening visit.
• •Intolerance or contra-indication to treatment with beta2-agonists and/or inhaled corticosteroids.
• •Allergy, sensitivity or intolerance to study drugs or excipients.
• •Significant medical history of and/or treatments for cardiac, renal, neurological, hepatic, endocrine diseases, or any laboratory abnormality.