Lead Sponsor

Georgetown University

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Histologically confirmed adenocarcinoma of the pancreas
•Prior treatment for distant or locally advanced disease with gemcitabine-based therapy
•Measurable or evaluable disease
•ECOG performance status 0-2
•Adequate hematological parameters
•Adequate baseline liver function
•At least 28 days from any major surgery
•At least 2 weeks from the last radiation treatment
•Must have recovered from reversible toxicities of prior chemotherapy
•Must be able to discontinue any nonsteroidal anti-inflammatory medications
•Must be willing to receive intramuscular vitamin B12 shots and take oral folate supplements

•Any prior treatment with pemetrexed
•More than one prior chemotherapy regimen
•HIV positive on antiretroviral therapy
•Pregnant or lactating
•Prior organ allograft
•On concurrent antitumor therapy including radiation therapy or other chemotherapies
•Creatinine clearance 45 ml/min or less
•Absolute neutrophil count \< 1500
•Platelets \< 75,000
•Bilirubin \> 1.5 times the upper limit of normal
•Transaminases \> 3 times the upper limit of normal except in known liver metastasis wherein they may be \</= 5 times upper limit of normal
•Clinically significant ascites or pleural effusion that cannot be drained
•Any medical or psychiatric condition that may interfere with the ability to comply with protocol treatment