Comparison of ATG to Thymoglobuline in Renal Transplantation

Exclusion Criteria

• •1. Patient is pregnant or breastfeeding.
• •2. Patient has a low immunological risk constellation, defined by receiving a kidney from a HLA-identical related living donor.
• •3. Patient and donor have a positive T-cell crossmatch.
• •4. Patient and donor are ABO incompatible.
• •5. Patient with combined transplantation.
• •6. Age of donor \>75 years.
• •7. Cold ischemia time \>40 hours.
• •8. Patient has leucopenia, defined as having at transplantation less than 3000/mm3 leukocytes.
• •9. Patient has thrombocytopenia, defined as having at transplantation less than 75000/mm3 thrombocytes.
• •10. Patient is allergic or intolerant to ATG-Fresenius S, Thymoglobulin, steroids, Tacrolimus or MMF.
• •11. EBV risk constellation (recipient EBV negative and donor EBV positive).
• •12. Patient or donor is known to be HIV positive.
• •13. Patient has a liver disease, defined as continuously having ASAT (SGOT) and/or ALAT (SGPT) levels greater than 3fold of the upper value of the normal range of the investigational site during the past 28 days.
• •14. Patient with malignancy or history of malignancy \<2 years, except non metastatic basal or squamous cell carcinoma of the skin that has been treated successfully.
• •15. Patient has uncontrolled concomitant infections and/or severe diarrhea, vomiting, or active peptic ulcer.
• •16. Patient is unlikely to comply with the visits schedule in the protocol.