Study to Assess the Safety and Efficacy of CD-NP in the Treatment of Patients With Acute Decompensated Heart Failure

Exclusion Criteria

• •1. Acute or suspected acute myocardial infarction (AMI) or troponin levels \> 3X the upper limit of normal at the institution's local laboratory
• •2. Cardiogenic shock
• •3. Evidence of uncorrected volume or sodium depletion other clinical condition that would predispose the patient to adverse events
• •4. Clinically significant aortic or mitral valve stenosis
• •5. Temperature \>38°C (oral or equivalent), sepsis or active infection requiring IV anti-microbial treatment
• •6. ADHF due to significant arrhythmias
• •7. Severe renal failure defined as creatinine clearance \< 30 mL/min
• •8. Current or planned ultrafiltration, hemofiltration, or dialysis
• •9. Significant pulmonary disease
• •10. Major neurologic event, including cerebrovascular events in the prior 60 days.
• •11. Acute myocarditis or hypertrophic obstructive, restrictive, or constrictive cardiomyopathy (not including restrictive mitral filling patterns)
• •12. Known hypersensitivity or allergy to natriuretic peptide or its components, nesiritide, other natriuretic peptides or related compounds