Effect of Ketamine on Opioid-Induced Hyperalgesia

Exclusion Criteria

• •1. Subject has an altered sensation at the skin site of QST (one of upper extremities).
• •2. Subject has scar tissue or acute injury at the skin site of QST.
• •3. Subject has neurological disease or a condition causing upper extremities or generalized polyneuropathy, such as diabetic neuropathy, alcoholic neuropathy, AIDS neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, and post-stroke residual neurological deficits.
• •4. Subject has a diagnosis of renal or liver failure.
• •5. Subject has a diagnosis of unstable angina, congestive heart failure, cardiac arrythmias or myocardial infarction within 1 year.
• •6. Subject is allergic to ketamine.
• •7. Subject had recent therapy that may influence QST results, e.g., neuroablative procedure involving upper extremities within six-months or peripheral neurolytic block involving upper extremities within two-months.
• •8. Subject has a confirmed diagnosis of and is under the care of a psychiatrist for major depression disorder, eating disorder; alcohol or drug dependence; or attention deficit hyperactivity disorder. Subject has any history of a confirmed diagnosis of bipolar disorder, schizophrenia, anxiety disorder or a psychotic disorder
• •9. Subject is tested positive on drug urine screening test.
• •10. Subject is pregnant or breast-feeding.
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