A Study of KRN23 in X-linked Hypophosphatemia

Exclusion Criteria

• •1. Have any sign of active infectious disease or have had an infection requiring treatment with antibiotics within three weeks prior to screening
• •2. History of known immunodeficiency
• •3. Lactating females, female patients who are pregnant or planning to become pregnant during the study
• •4. Use of a pharmacologic vitamin D metabolite or its analog, phosphate, calcimimetics, and ingestion of aluminum hydroxide antacids within 10 days prior to screening and dosing
• •5. Use of any supplement contained phosphate, calcium and/or vitamin D within 10 days prior to screening and dosing
• •6. Receipt of live (attenuated) vaccine within 3-months prior to screening
• •7. Have any condition which, in the opinion of the Investigator, could present a concern for either patient safety or difficulty with data interpretation