1. Men or women of nonchildbearing potential, 18 to 50 years of age inclusive at screening.

2. Body mass index (BMI) in the range of 18 to 32 kg/m2 and body weight greater than or equal to 50 kg.

3. Healthy as determined by the investigator on the basis of the screening evaluations.

4. Nonsmoker of smoker of fewer than 10 cigarettes per day as determined by history.

Study Evaluating Single Doses of BLI-489 in Healthy Subjects