Ramipril Versus Carvedilol in Duchenne and Becker Patients

Exclusion Criteria

• •1. Failure to obtain informed consent from patients, parents or guardians.
• •2. Any controindications to carvedilol or ramipril treatment (bronchial asthma, diabetes, any degree of renal failure (all patients are required to have a normal creatinine level and clearance).
• •5. DMD and BMD patients requiring ventilatory (non-invasive or invasive) assistance.
• •6. Presence of systolic and/or diastolic dysfunction detected by 2D-Echocardiography.
• •7. Presence of any contraindications to CMR (including any history of claustrophobia).
• •8. Patients under the age of 2 years.
• •9. Renal failure, even mild.
• •10. Patient unable or unwilling to attend the follow-up and tests, in the opinion of local study principal investigator, (children not willing to perform CMR will not be enrolled).