No prior therapy for GBM, except for primary surgical resection or biopsy
PS 0-2
Age \> 18
Expected survival \> 3 months
Adequate liver, renal and bone-marrow function, determined as:
* Thrombocytes \> 100 x 109/liter
* Hemoglobin \>6.2 mmol/liter
* Leukocytes \> 3 x 109/liter
* Neutrophil granulocytes \> 1.5 x 109/liter
* ASAT and/or ALAT \< 3 x upper normal limit
* Bilirubin \< 1.5 x upper normal limit
* Serum-creatinin \< upper normal limit or glomerular filtration rate \>60 ml/min (corrected for age) determined by measurement of clearance of Cr-EDTA
* APTT \< upper normal limit
* INR \< upper normal limit
Fertile women of childbearing age must use proper anti-conception (oral contraceptives, IUD and/or condom). Fertile men must use condom
No sign of cerebral bleeding on cerebral MR-scanning at baseline.
You may not be if
Previous therapy of GBM, including radiotherapy and the use of biological " targeted" drug, e.g. drugs targeted against the VEGF- or EGFR pathway
Concurrent use of medication that can affect the interpretation of the results from the study, e.g. use of immunosuppressive drugs, except corticosteroids
Conditions (medical, social or physical) that may compromise proper information and/or follow-up
Other concurrent or previous cancer within 5 years, except adequately treated basal or planocellular skin cancer, or cervical carcinoma in situ
Significant heart disease (according to the New York Heart Association class II or more severe), clinically significant arrhythmia or unstable angina pectoris/acute myocardial infarction within last 6 months
Clinical significant peripheral arterial disease
Known or suspected disorders of coagulation or concurrent therapy with ASA, NSAID or clopidogrel
Major surgery, open biopsy or greater trauma, or expectations thereof, within 28 days prior to start of therapy
Minor surgery or needle biopsy, or expectations thereof, within 7 days prior to start of therapy
Known or suspected abdominal fistulas, gastrointestinal perforations or intra-abdominal abscesses within 6 months prior to start of therapy
