Current manic, hypomanic or mixed episode

Rapid cycling bipolar disorder (4 or more mood episodes in the last year)

Dementia or any other Axis I diagnosis (besides bipolar I) that requires treatment

Alcohol or drug dependence within 6 months; alcohol or drug abuse within 3 months

Positive urine drug test for amphetamines, cocaine metabolites, opiates and/or phencyclidine(PCP)

Axis II diagnosis likely to interfere with study compliance

Serious suicidal or homicidal risk

Sensitivity to any of the drug ingredients, including lactose

Women who are pregnant, breast feeding or refuse to use adequate birth control

Current seizure disorder

Current episode of depression is longer than 1 year

A Study to Assess the Safety, Tolerability and Efficacy of RG2417 in Bipolar I Depression