exclusively atypical symptoms of GERD

symptoms that have been shown not to be associated with GERD

erosive oesophagitis

treated with a dose of PPI greater than the dose indicated for clinical symptom control of GERD

hiatus hernia \> 3 cm

current diagnosis of co-existing psychiatric disease

known clinical significant allergy or known hypersensitivity to drugs

is pregnant or breast-feeding

has received sodium valproate or topiramate within 30 days of Screening

has a history of a significant medical condition that may affect the safety of the patient or preclude adequate participation in the study

ADX10059 as an add-on Therapy to Proton Pump Inhibitors (PPIs) in Patients With Gastroesophageal Reflux (GERD)