Pilot Study to Validate Metallic Markers for Image Guided Radiation Therapy for Breast Cancer Tx

Exclusion Criteria

• •Pregnant or breast feeding at time of study entry. Note: Radiation therapy is teratogenic. Women of child bearing potential must agree to use adequate contraception (abstinence, hormonal or barrier method of birth control) prior to and during study participation. Should a woman become pregnant, she should inform the treating physicians immediately.
• •Prior in-field irradiation
• •Stage III or IV breast cancer
• •Inability to place intraparenchymal metallic markers due to excessive bleeding or other intraoperative complication so that the surgeon deems it inadvisable to place the marker
• •Pathologic tumor size \>/= 5 cm
• •Positive or unassessed margins of surgical resection
• •Diffuse calcifications on mammogram pre- or post-operatively
• •Positive or suspicious post-lumpectomy mammogram or breast magnetic resonance imaging (MRI)
• •Multicentric carcinoma in more than one quadrant of the breast
• •Non-epithelial breast malignancy; Paget's disease of the nipple
• •Personal history of collagen vascular disease clinically judged to be a contraindication to radiation therapy
• •Recurrent disease or prior history of ipsilateral breast cancer
• •Psychiatric or addictive disorders that impair patient's voluntary ability to participate in informed consent or protocol procedures