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COMPLETEDPhase 1NCT00800722

A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.

The purpose of this study is to improve port wine stain therapeutic outcome in response to laser therapy. The researchers want to determine whether the combined use of pulsed dye laser therapy and rap...

Lead sponsor: University of California, Irvine•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of California, Irvine

Collaborators

Pfizer
Beckman Laser Institute University of California Irvine

The researchers want to combined use of pulsed dye laser to induce port wine stain blood vessel injury, and rapamycin directly inhibits the proliferation of vascular endothelial cells driven by vascular endothelial growth factor which preventing port wine stain angiogenesis and recanalization, to improve port wine stain lesion blanching.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•port wine stain birthmarks suitable for comparison testing.

Exclusion Criteria

•Pregnancy.
•Abnormal blood hematology or chemistry blood tests or urine analysis.
•History of cancer, History of high cholesterol, lipids or liver disease
•Allergy to macrolide drugs (e.g., erythromycin).
•Any therapy within the previous two months to the proposed PWS treatment sites.
•Concurrent use of known photosensitizing drugs,immunosuppressive drugs or systemic steroids,antifungals, antiepileptics, HIV protease inhibitors, cimetidine, cisapride, clarithromycin, dannzol, diltiazem, erythromycin, metoclopramide, rifabutin, rifampin, rifapentine, troleandomycin, or verapamil.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: November 1, 2022Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE1

Enrollment21

Start dateNov 2008

Last updatedNov 1, 2022

Condition

Port Wine Stain

Locations shown

Beckman Laser Institute Medical clinic

Irvine, California

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 1, 2022Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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