Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
VA Boston Healthcare System
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Eligible participants for this study:
Are between the ages 18-65 years of age
Are daily cigarette smokers
Have smoked a minimum of 10 cigarettes per day for at least one year
Are confirmed smokers as verified by CO
Have a psychiatric diagnosis of schizophrenia or schizoaffective disorder (any subtype) as determined by the SCID-IV. Participants must have received a stable dose of antipsychotic medication for at least 2 weeks prior to beginning the study. Patients receiving clozapine at 500 mg/day or more must also be receiving anti-seizure prophylaxis. Patients must be determined to be psychiatrically stable at baseline as established by standardized interview and medical review by psychiatrist.
There currently are no known contraindications to the use of varenicline and no identified drug-drug interactions. However, reduced dosage of varenicline is recommended for individuals with severe renal impairment.
You may not be if
Any serious or unstable medical problem in the last 6 months
Severe renal impairment
A history of clinically significant allergic reactions to nicotine agonist medications
Current primary use of tobacco products other than cigarettes
Breath alcohol level \> 0.005 g/l at screening
Current substance abuse or dependence (besides nicotine)
Current attempts to quit smoking using any method
Designation as legally incompetent to sign the informed consent (i.e., have a guardian or have delegated power of attorney to another).
Other exclusions are:
Current use of medications that might affect the behavioral response to cigarette smoking, including transdermal nicotine or nicotine gum and bupropion - Inability to participate in the screening session due to severe psychosis, severe depression or suicidality, current mania, or an organic mental disorder such as dementia or delirium
Presence of unstable psychiatric symptoms or clinical deterioration (i.e., unstable psychosis, homicidality, or suicidality) within the last month.
Clareo Health | Treating Schizophrenic Smokers: Effects on Craving, Cues and Withdrawal
