A Study to Evaluate the RNA Signature of Rheumatoid Arthritis From Synovium and Whole Blood

Inclusion Criteria

• •Adult men and non-pregnant, non-lactating women between 18 and 75 years of age. Sexually active females must be of either non-childbearing potential or willing to comply with the contraceptive requirements
• •Body weight greater \>40 kg and \<120 kg with a body mass index (BMI) between 19-31 kg/m2
• •Clinical history of rheumatoid arthritis as defined by ACR criteria
• •Negative urine pregnancy test for women of child bearing age (except those with documented proof of hysterectomy or bilateral oophorectomy)
• •For populations B and C only
• •Currently on a stable dosing regimen of methotrexate 7.5 to 25 mg once weekly, as their only DMARD (no changes in dosing regimen for 4 weeks prior to screening).