Lead Sponsor

Novartis

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Newly diagnosed patients or patients who have not been treated for hypertension within the 4 weeks prior to Visit 1 must have a mean sitting Diastolic Blood Pressure (msDBP) ≥ 95 mmHg and \< 110 mmHg at Visits 1 and 2
•Patients who have been treated for hypertension within the 4 weeks prior to - Visit 1 must have a msDBP ≥ 90 mmHg and \< 110 mmHg at Visit 2
•All patients must have a msDBP ≥ 90 mmHg and \< 110 mmHg at Visit 4

•Severe hypertension
•Pregnant or nursing (lactating) women
•Women of child-bearing potential
•Previous or current diagnosis of heart failure New York Heart Association (NYHA Class II-IV)
•Serum potassium ≥ 5.3 mEq/L (mmol/L) at Visit 1
•Uncontrolled Type 1 or Type 2 diabetes mellitus
•Hypersensitivity to renin inhibitors, calcium channel blockers, or to drugs with Similar chemical structures
•History of hypertensive encephalopathy or cerebrovascular accident, or history of transient ischemic attack (TIA), myocardial infarction, coronary bypass surgery, or any percutaneous coronary intervention