Subcutaneous Rehydration Compared to Intravenous Rehydration

Exclusion Criteria

• •Severe dehydration
• •Shock or life-threatening situation (life expectancy \< 10 days).
• •Requirement for IV access for any indication other than for treatment of dehydration.
• •Indwelling IV catheter, except for one intended only for collection of clinical laboratory specimens.
• •Any condition precluding SC infusion or infusion site evaluation
• •Any reason (prior to study enrollment) for a hospital admission or an extended stay in the ED for other than dehydration.
• •Known hypersensitivity to hyaluronidase or hylenex.
• •Known hyponatremia (\< 130 milliequivalents per liter \[mEq/L\]) or hypernatremia (\> 155 mEq/L).
• •Known hypokalemia (\< 3.0 mEq/L).
• •Any medical condition likely to interfere with the patient's ability to fully complete all protocol-specified interventions, the ability to undergo all protocol-specified assessments, or likely to prolong the patient's need for medical attention beyond that required for treatment of dehydration.
• •Participation in an investigational drug or device study within 30 days prior to enrollment in this study.