Age

20–75

Sex

ALL

Healthy volunteers

Not accepted

Male and female
20 years or older and less than 75 years
Outpatient
Untreated or treated patients with antihypertensive agents whose blood pressure (BP) in sitting position at entry (Visit 1) is as follows.
* Untreated patients: systolic blood pressure (SBP) \>= 160mmHg or diastolic blood pressure (DBP) \>= 100mmHg
* Treated patients: SBP \>= 140mmHg or DBP \>= 90mmHg (at trough)

Patients whose BP during baseline treatment period is: SBP\>=200mmHg or DBP\>=120mmHg.
Patients with secondary hypertension or hypertensive emergency.
Patients with cardiovascular or cerebrovascular ischemic event (stroke, transient ischemic attack (TIA), myocardial infarction or unstable angina), or with history of these within 6 months prior to the study.
Patients with intracranial or subarachnoid hemorrhage, or with history of these within 6 months prior to the study.
Patients with server hematopoietic dysfunction (acute/chronic leukemia, myeloma, malignant lymphoma, myelodysplastic syndrome, aplastic anemia), or with history of these.

Nifedipine (Adalat CR, BAY A1040) High Dose PK/PD Study