1. Women who are pregnant or in lactation

2. Patients with hyperostosis

3. with brain metastasis(exception of those without symptom or with Metastasis Lesions under controlled

4. Previous or current treatment with any other bisphosphonates, bone- protecting, cytotoxic or targeted therapy

5. Severe co-morbidity of any type that may interfere with assessment of the patient for the study -

Screening Non Small Cell Lung Cancer With Bone Metastasis and Efficacy and Safety Research of Receiving Bisphosphonates