The Interaction Between Calcium and Vitamin D Intake

Exclusion Criteria

• •Any chronic medical illness including uncontrolled diabetes mellitus, recent history of myocardial infarction, or heart failure, malignancy, uncontrolled hypertension, obesity (BMI\>35 kg/m2), history of anemia, leukemia, or other hematologic abnormalities, lupus, rheumatoid arthritis, or other rheumatologic disease, or kidney disease of any kind as determined by history and physical examination.
• •Subjects with osteoporosis of the hip (total hip T-score equal or less than -2.5) or taking medications for osteoporosis such as bisphosphonates will be excluded.
• •Pregnancy.
• •Use of medication that influences bone metabolism (i.e. anticonvulsant medications, chronic use of steroids and high dose diuretics).
• •Significant deviation from normal in medical history, physical examination, or laboratory tests as evaluated by the primary investigator.
• •Patients with a history of hypercalciuria, hypercalcemia, nephrolithiasis, and active sarcoidosis will also be excluded.
• •Participation in another investigational trial in the past 30 days prior to the screening evaluation.
• •Unexplained weight loss of \>15% during the previous year or history of anorexia nervosa.
• •Medications that interfere with vitamin D metabolism.
• •Patients with a habitual dietary calcium intake that exceeds 800 mg/day.
• •Smokers greater than 1 pack per day will be excluded.
• •Patients reporting alcohol intake greater than 2 drinks daily.
• •Serum 25-hydroxyvitamin D level \> 75 nmol/L.