Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Lund University Hospital
With
Bayer
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Written informed concent
Age at least 18 years
WHO Performance status 0-3
Histologically verified B-cell lymphoma
Diffuse large B-cell lymphoma and follicular grade III, failing an anthracycline containing regimen and patients not found suitable for a second line chemotherapy consolidated by high dose chemotherapy (HDCT) with stem cell support or radiotherapy
Transformed B-cell lymphoma, failing first line therapy and not suitable for high dose chemotherapy (HDCT) or with a history of HDCT with stem cell support
Follicular lymphoma grade II and I, and other indolent lymphomas must have failed second line treatment.
One of these treatments must have contained chemotherapy and rituximab, the latter either together with chemotherapy or as maintenance.
The lymphoma must require treatment, Mantle cell lymphoma, failing first line treatment,treatment required
Measurable disease and the tumor burden must be acceptable according to the investigator
Radiological studies must be performed and a unilateral bone marrow biopsy within 4 weeks before start of treatment
Bone marrow reserve likely to give a harvest of at least 2x10 6 peripheral CD34+ stemcells or the existence of such a harvest or a corresponding central harvest
Total bilirubin should not exceed 40 micromole/L
A GFR as measured by Cystatin C of 50 ml/min
HIV, Hepatitis B and C status known
Life expectancy of at least 3 months.
You may not be if
Known or clinical evidence of CNS involvement
Bone marrow involvement at harvest as measured by biopsy and flow cytometry
Subjects with prior radiation to a field that includes over or equal 25% of their red marrow, liver or lung or to both kidneys
Prior chemotherapy or radiotherapy within 4 weeks
Subjects who are pregnant or nursing
Pulmonary involvement, that is not negligible at the discretion of the investigator
Liver involvement of lymphoma
History of hepatitis B or C.
Clareo Health | High Dose, Absorbed Dose Adjusted 90Y-ibritumomab With Peripheral Blood Stem Cells (PBSC) Support in B-cell Lymphoma
