A Multiple Ascending Dose Study of RO4905417 in Healthy Volunteers and Patients With Peripheral Arterial Disease (PAD).

Inclusion Criteria

• •healthy males and females aged 18-65 years (Arms 1,2,5,6,9,10);
• •BMI 18-30kg/m2 (Arms 1,2,5,6,9,10);
• •males and females aged 45-75 years with confirmed stable PAD (Arms 3,4,7,8,11,12);
• •on a stable dose of statin, aspirin or clopidogrel for at least one month prior to the study (Arms 3,4,7,8,11,12);
• •BMI 17.5-35kg/m2 (Arms 3,4,7,8,11,12).