A Comparison of Azopt Versus Placebo Added to Xalatan in Patients With Elevated Intraocular Pressure (IOP) on a Prostaglandin

Inclusion Criteria

• •Unilateral or bilateral primary open angle glaucoma, ocular hypertension or pseudoexfoliation syndrome.
• •Intraocular pressure greater than 18 mmHg (mean diurnal) and less than 32 mmHg.
• •Exclusion:
• •Previous intraocular surgery, except uncomplicated clear cornea phacoemulsification or argon laser trabeculoplasty.
• •Argon laser trabeculoplasty or phacoemulsification within the last 3 months.
• •Central corneal thickness outside the 500 - 600 (inclusive) micron range as measured by ultrasonic pachymetry.
• •Ocular or periocular inflammation within 3 months prior to study (except blepharitis related or seasonal allergic conjunctivitis).
• •History of uveitis or previous intraocular inflammation (other than post-operatively).
• •Hypersensitivity to sulfa, or benzalkonium chloride.
• •History of use of any steroids for over 1 week within 3 months of screening or likely need for any corticosteroids during the study (except inhaled, nasal or topical non-ocular).