Finding studies
Finding studies
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Lead
Loyola University
With
OBJECTIVES To evaluate the safety and tolerability of the gamma-secretase inhibitor MK-0752 in the pre-surgical setting in patients with early stage, estrogen receptor (ER) positive breast cancer, in combination with tamoxifen or an aromatase inhibitor (AI). To establish the feasibility and success of multi-laboratory collaborations in evaluating clinical specimens and biomarker testing. To provide preliminary data on the impact of MK-0752 on a panel of biomarkers involved in the notch signaling pathway.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted