AZD1386 Japanese Multiple Ascending Dosing Study

Exclusion Criteria

• •History of somatic or psychiatric disease/condition, which may interfere with the objectives of the study as judged by the investigator
• •A family history of short or long QT syndrome (SQTS) or sudden cardiac death (SCD) amongst first degree relatives
• •Subjects with orthostatic hypotension defined as a decrease of ≥ 25mmHg systolic blood pressure and/or a decrease of ≥15mmHg diastolic blood pressure within 5 minutes when going from a supine to standing position
• •Clinically significant illness or clinically relevant trauma within 2 weeks prior to the administration of the investigational product as judged by the investigator