Prior treatment with radiation and one first line systemic therapy (including temozolomide or other chemotherapy, immunotherapy, targeted therapy or combination therapies), followed by measurable and unequivocal evidence of tumor progression or recurrence
Age ≥ 18 years
ECOG ≤ 2
Normal organ and marrow function as defined below:
* leukocytes ≥3 x 109/L
* absolute neutrophil count ≥1.5 x 109/L
* platelets ≥100 x 109/L
* hemoglobin ≥90 g/L
* total bilirubin ≤2.5 X institutional upper limit of normal
* AST(SGOT)/ALT(SGPT) ≤2.5 X institutional upper limit of normal
* creatinine ≤1.0 X institutional upper limit of normal
You may not be if
Patients with a life expectancy \< 12 weeks
Patients with a documented history of HIV, active hepatitis B or C infections
Female patients who are pregnant or lactating
Patients in whom a proper central line (Portacath-like device) cannot be established
Patients with a known hypersensitivity to farnesylated dibenzodiazepinone or polysorbate 80
Patients with uncontrolled hypotension
Patients with concomitant therapy of therapeutic coumadin
