Zonisamide SR Plus Bupropion SR Combination Therapy in Subjects With Obesity

Exclusion Criteria

• •Obesity of known endocrine or genetic origin (e.g., untreated hypothyroidism, Cushing's syndrome, polycystic ovary syndrome)
• •Serious medical condition
• •History of malignancy within the previous 5 years, with exception of non-melanoma skin cancer or surgically cured cervical cancer.
• •History of suicide attempt or serious psychiatric illness
• •History of Major Depressive Disorder within the past 2 years
• •In need of medications for the treatment of a psychiatric disorder (with the exception of short-term insomnia) within the previous 6 months prior to randomization
• •Type I or Type II diabetes
• •History of alcohol or drug abuse or dependence as determined by the Investigator within 1 year prior to randomization
• •History of surgical or device (e.g. gastric banding) intervention for obesity
• •History of seizures or predisposition to seizures
• •History of hypersensitivity to sulfonamides ("sulfa"), bupropion, or zonisamide
• •History of treatment with bupropion SR (Wellbutrin, Zyban) or zonisamide (Zonegran) within previous 12 months
• •History of nephrolithiasis (renal calculi)
• •Loss or gain of more than 4.0 kg within 3 months prior to randomization
• •Women of child bearing potential not adhering to a medically acceptable form of contraception
• •Pregnant or breast-feeding women or planning to become pregnant during the study period or within 30 days of discontinuing study drug