Trial of Partial Breast Irradiation With Various Concurrent Chemotherapy Regimens

Inclusion Criteria

• •Eligibility Criteria:
• •Each of the criteria in the following section must be met in order for a patient to be considered eligible for registration.
• •Patient must be older than 18 years of age
• •Patient must have a Medical Oncology consult and be recommended to receive one of the following regimens: Cyclophosphamide and Doxorubicin (AC); Taxotere, Doxorubicin and Cyclophosphamide (TAC); Taxotere and Cyclophosphamide (TC) or Taxotere, Carboplatin and Trastuzumab (TCH) prior to registration. The use of additional chemotherapy, hormonal therapy or Trastuzumab after the initial regimen is at the discretion of the medical oncologist.
• •Patients must be registered such that radiation therapy begins no sooner than 7 days prior to, but no later than 7 days after, day 1 of cycle 1 (C1D1). Patient must start chemotherapy and radiation less than 14 weeks from the last breast surgical procedure.
• •Patients must NOT have received any neo adjuvant chemo or hormonal therapy for the current cancer.
• •Patients must have a performance status 0 or 1 by ECOG criteria
• •Patients must not have received prior radiation therapy to the involved breast at any time for any reason.