Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of California, San Francisco
Age
18–100
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patient's + 18 years with suspected pre-capillary pulmonary hypertension
Prescribed Endothelial - 1 receptor blocker
You may not be if
Currently taking endothelium-active vasodilator therapy.
Hemoglobin and / or hematocrit level blood the lower normal limit.
Left ventricle dysfunction (LVEF \<50%)
LV end-diastolic pressure \> 15 mmHg)
Recent history (\<3 months) of pulmonary embolism
Liver failure or abnormal liver function tests; aortic or mitral regurgitation or stenosis
Current medication with endothelin-1 receptor antagonist, prostacyclin analogues or type 5 phosphodiesterase inhibitors.
Subjects with conditions known to be associated with an increase in circulating endothelial microparticle numers, such as chronic renal failure (Creatinine Clearance \< 50 ml/min/m2) acute coronary syndromes and uncontrolled system hypertension.
